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资源简介：
Targeted sequencing of ~450 cancer genes in 38 pairs of cancer cell lines and their Cas9-expressing derivatives
应用场景：
创建时间：
2020-04-01
相关数据集
Improved inference of site-specific positive selection under a generalized parametric codon model when there are multinucleotide mutations and multiple nonsynonymous rates
Background: An excess of nonsynonymous substitutions, over neutrality, is considered evidence of positive Darwinian selection. Inference for proteins often relies on estimation of the nonsynonymous
NIAID Data Ecosystem150
Generation of in vivo murine models of myeloid malignancy with combinatorial genetic lesions using CRISPR/Cas genome editing. Mus musculus strain:C57BL/6
Generation of in vivo murine models of myeloid malignancy with combinatorial genetic lesions using CRISPR/Cas genome editing
NIAID Data Ecosystem110
Generation of Ugt1-Deficient Murine Liver Cell Lines Using TALEN Technology
The Crigler-Najjar Syndrome Type I (CNSI) is a rare genetic disorder caused by mutations in the Ugt1a1 gene. It is characterized by unconjugated hyperbilirubinemia that may result in severe neurologic
Figshare2016-01-15 更新50
Macrophages from Rosa26-integrated Cas9-expressing C57BL/6 mice have a putative TRIF-mediated defect in the TLR-3/4 signaling
In this study, we report that the TLR4 ligand, LPS, and TLR3 ligand polyinosinic:polycytidylic acid failed to activate IRF3 or STAT1 in bone marrowâderived macrophages (BMMs) isolated from two indep
NIAID Data Ecosystem120
Shc proteins in DMBA induced breast cancer
The principal factors that control mammary tumor formation remain insufficiently defined. Shc adaptor proteins play an important role in signaling by three well-established biological markers for prog
NIAID Data Ecosystem100
