<b>The Role of Gut Microbiota and Plasma Metabolites in Osteoporosis: Insights from Mendelian Randomization Analysis</b>

Table 1 Instrumental variables of gut microbiota after clumping and exclusion of week IVsTable 2 Instrumental variables of plasma metabolites after clumping and exclusion of week IVsTable 3 Causal effects of gut microtiota on osteoporosis (Forward MR analysis)Table 4 Causal effects of osteoporosis on indentified gut microbiota (Reverse MR analysis)Table 5 Genetic correlation between identified gut microbiota and osteoporosis (LDSC analysis)Table 6 Causal assciations between plasma metabolites and osteoporosis (Associations only with PIVW less than 0.05 and consistent with all sensitivity analysis were listed)Table 7 Causal assciations between identified gut microbiota and 91 plasma metabolitesTable 8 Mediantion analysis between gut microbiota, plasma metabolites, and osteoporosis

表1 经聚类处理并剔除弱工具变量后的肠道菌群工具变量
表2 经聚类处理并剔除弱工具变量后的血浆代谢物工具变量
表3 肠道菌群对骨质疏松的因果效应（正向孟德尔随机化（Mendelian Randomization, MR）分析）
表4 骨质疏松对已鉴定肠道菌群的因果效应（反向孟德尔随机化分析）
表5 已鉴定肠道菌群与骨质疏松之间的遗传相关性（连锁不平衡得分回归（Linkage Disequilibrium Score Regression, LDSC）分析）
表6 血浆代谢物与骨质疏松的因果关联（仅列出工具变量逆方差加权法P值小于0.05且与所有敏感性分析结果一致的关联）
表7 已鉴定肠道菌群与91种血浆代谢物之间的因果关联
表8 肠道菌群、血浆代谢物与骨质疏松之间的中介分析

搜集汇总

背景与挑战

背景概述

该数据集通过孟德尔随机化分析，探讨肠道微生物群和血浆代谢物与骨质疏松症之间的因果关系，包含工具变量、因果效应、遗传相关性和中介分析等8个表格的原始数据。数据集发布于2024年，属于医学细菌学领域，采用开放许可证，旨在为骨质疏松症的病因研究提供实证支持。