Investigating anti-PD-1 antibody resistance in melanoma

NIAID Data Ecosystem2026-03-10 收录

癌细胞耐药性

黑色素瘤基因表达与功能

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA487171 数据链接链接失效反馈

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资源简介：

RNAseq differential gene expression analysis was performed on melanomas following their escape from anti-PD-1 antibody immunotherapy versus those progressing through an isotype control antibody in the transgenic BRAF(V600E)-PTEN-/- murine melanoma model.

创建时间：

2018-08-22

Variability within rare cell states enables multiple paths towards drug resistance [WM989_WM983b]. Variability within rare cell states enables multiple paths towards drug resistance [WM989_WM983b]

癌细胞耐药性

单细胞分析

Molecular differences between individual cells can lead to dramatic differences in cell fate, such as the difference between death versus survival of cancer cells upon treatment with anti-cancer drugs

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Expression data from human colonic cancer cell line SW480 and its acquired 17-AAG resistance cell line SW480-R

癌细胞耐药性

基因表达谱分析

Heat shock protein 90 (HSP90) is a molecular chaperone required for the stability and function of many proteins. The chaperoning of oncoproteins by HSP90 enhances survival, growth and invasive potenti

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Role for TNFAIP2: Relationships with Outcomes and EMT in Urothelial Cancers under the Control of Cisplatin. Role for TNFAIP2: Relationships with Outcomes and EMT in Urothelial Cancers under the Control of Cisplatin

癌细胞耐药性

上皮-间质转化调控

Background: Cisplatin (CDDP)-based chemotherapy is the gold standard treatment for many cancer types. However, the phenotypic hallmark of tumors often changes after CDDP, with the acquisition of Epith

NIAID Data Ecosystem20

Gene expression in xenograft tumors derived from HCT116 and its oxaliplatin resistant clones. Gene expression in xenograft tumors derived from HCT116 and its oxaliplatin resistant clones

癌细胞耐药性

奥沙利铂

To explore the mechanisms associated with oxaliplatin resistance, we compared gene expression in xenograft tumors derived from human colorectal cancer tumor cells HCT116 and its oxaliplatin resistant

NIAID Data Ecosystem30

Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance [RNA-Seq]. Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance [RNA-Seq]

癌细胞耐药性

药物联合治疗

We show that high DCTPP1 expression was associated with cell-intrinsic resistance to nucleoside DNMT inhibition, and that triptolide and its analogs could overcome this resistance. Overall design: mRN

NIAID Data Ecosystem20

Investigating anti-PD-1 antibody resistance in melanoma

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