BackgroundMelanin-concentrating hormone receptor 1 (MCHR1) plays a significant role in regulation of energy balance, food intake, physical activity and body weight in humans and rodents. Several assoc
Characterisation of Polycomb complex assemblies in quiescent and cycling human fibroblasts Overall design: RNA-Seq, Chip-seq (H3K27me3, H3K27me2, H3K27me1) and Chip-Rx (EZH1, EZH2, EED,CBX7, PHC1, CBX
Gene expression is controlled by a variety of proteins (the epigenome) whose precise organization and mechanism of action at every promoter remains to be worked out. Here we examine a functionally div
Crystal structure of the MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L complex Descriptor: Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Z
RNA-Seq of human endothelial cells treated with ACF revealed massive changes on gene expression. These were non-randomly and strongly conserved to murine lung endothelial cells potentially due to DNA