<strong> The Causal Relationship between Thyroid Volume and Thyroid Disease: A Mendelian Randomization Study</strong>

<strong>supplemental file for peer review</strong> 1.Supplementary Figure 1: Scatter plot for genetically predicted thyroid volume on thyroid diseases. Inverse variance weighted, weighted median, MR-Egger, simple mode and weighted mode slopes represent results from these regression analyses. 2.Supplementary Table 1: Information about the selected databases. 3.Supplementary Table 2: Information on the selected SNPs. 4.Supplementary Table 3: Five MR Methods estimate the causal effect of thyroid volume on thyroid disease and TSH. 5.Supplementary Table 4: Testing for genetic pleiotropy.