Expedient Synthesis of Furo[2,3-d][1,3]thiazinamines and Pyrano[2,3‑d][1,3]thiazinamines from Enones and Thiourea
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Michael addition of thiourea to enones with subsequent intramolecular aminal ether formation provided easy access to furo[2,3-d]thiazinamines and pyrano[2,3-d][1,3]thiazin-2-amines. These amines served as versatile intermediates to a variety of beta-amyloid cleaving enzyme-1 (BACE1) inhibitors.
创建时间：
2016-04-11
