SY-1365, a covalent, first in-class CDK7 inhibitor for cancer treatment

NIAID Data Ecosystem2026-03-13 收录

靶向药物研发

CDK7抑制剂

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121431 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2021-10-19

Additional file 1: of Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery

癌细胞重编程

靶向药物研发

Table S1. Differentially expressed genes in high-PKM2 group. Table S2. Differentially expressed genes in low-PKM2 group. Table S3. Descriptive statistics of PKM2 and other clinical features grouped by

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HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR

蛋白质-抑制剂复合物解析

靶向药物研发

HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR Descriptor: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ACETIC ACID, CHLORIDE ION, ... Authors: Hakansson, M, Walse, B, Gust

Protein Data Bank Japan2024-01-17 更新20

Crystal structure of CDK2 liganded with compound WN333

蛋白-配体结构解析

靶向药物研发

Crystal structure of CDK2 liganded with compound WN333 Descriptor: 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-(methoxycarbonyl)benzoic acid, Cyclin-dependent kinase 2 Authors: Sun, L, Schonbr

Protein Data Bank Japan2023-10-25 更新00

Design and Synthesis of sEH/HDAC6 Dual-Targeting Inhibitors for the Treatment of Inflammatory Pain

炎症疾病治疗

靶向药物研发

Soluble epoxide hydrolase (sEH) and HDAC6 mediate the NF-κB pathway in inflammatory responses, and their inhibitors exhibit powerful anti-inflammatory and analgesic activities in treating both inflamm

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Additional file 4 of Cache: Utilizing ultra-large library screening in Rosetta to identify novel binders of the WD-repeat domain of Leucine-Rich Repeat Kinase 2

虚拟筛选

靶向药物研发

Supplementary material 4. Table S3: All improved 72 selected compounds and their SMILES code.

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