Maternal circulating microRNAs altered in fetal growth restricted pregnancies. Maternal circulating microRNAs altered in fetal growth restricted pregnancies

Total RNA isolated from maternal serum (drawn between 36-37 weeks gestation)from pregnancies with a growth restricted infant defined as an Individualised birthweight centile (IBC) < 3rd matched to a control pregnancy (IBC 20-80th), n=4 per group with 2 female and 2 male infants per group. Maternal serum miRNAs profiled using miRCURY LNA Universal RT miRNA PCR Human panel I + II to determine biomarker potential for prediction of growth restriction and sexually dimorphic patterns. Overall design: RT-qPCR microRNA expression profiling of total RNA isolated from maternal serum from women at 36weeks of pregnancy with growth restricted infant defined as an Individualised birthweight centile (IBC) < 3rd matched to a control pregnancy (IBC 20-80th), n=4 per group with 2 female and 2 male infants per group.