SeizeIT2

# README This dataset is a BIDS compatible version of the SeizeIT2 dataset. It reorganizes the file structure to comply with the BIDS specification. To this effect: - Metadata was organized according to BIDS. - Data in the edf files contains wearable EEG, ECG, EMG and movement data recorded with the Sensor Dot device. - Annotations were formatted as BIDS-score compatible `tsv` files. ### Contact person The dataset was published by [Miguel Bhagubai]([e-mail]) and [Christos Chatzichristos]([e-mail]). ## Overview ### Project name SeizeIT2 Dataset ### Year that the project ran 2024 ### Description of the dataset The SeizeIT2 project (clinicaltrials.gov: NCT04284072), a multicenter, prospective study, was carried out to validate the Sensor Dot device in adult and pediatric patients with epilepsy. Participants were included if they had a history of refractory epilepsy and were admitted to the Epilepsy Monitoring Unit (EMU) for long-term vEEG monitoring as a presurgical evaluation procedure. The exclusion criteria included patients with skin conditions or allergies that prevented the placement of the electrodes and adhesives or had implanted devices, such as neurostimulators or pacemakers. All participants provided written informed consent. The data collection started on January 10, 2020, and ended on June 30, 2022. The study was approved by the UZ Leuven ethics committee (approval ID: S63631, ClinicalTrials.gov, NCT04284072), anonymization and sharing of the data was also approved by the same committee (S67350 - amendment 1). The dataset comprises 125 patients (51 female, 41\%) from 5 different European EMUs: University Hospital Leuven (Belgium), Freiburg University Medical Center (Germany), RWTH University of Aachen (Germany), Karolinska University Hospital (Sweden) and Coimbra University Hospital (Portugal). The University Hospital Leuven was the only center that enrolled pediatric patients. The dataset includes only data from patients with focal epilepsy who experienced one or more seizure episodes during the monitoring period. ## Methods The participants were recorded with the specific center's vEEG monitoring equipment, where the EEG electrodes were placed according to the 10-20 system or the 25-electrode array of the International Federation of Clinical Neurophysiology. The SD device was used to record wearable data simultaneously with the vEEG. The device has a size of 24.5 x 33.5 x 7.73 mm and weighs approximately 6.3 grams. The wearable device measures data at a sampling frequency of 250 Hz and has a battery life of approximately 24 hours. Two recording devices were used: one placed in the patient's upper back using a patch and connected to electrodes attached behind the ear, on the mastoid bone (EEG SD); another placed on the left side of the chest, with two electrodes extended to the lower left rib cage and the fourth intercostal space in the left parasternal position to measure ECG, and two electrodes extended to the left deltoid muscle to measure EMG data (ECG/EMG SD). The module itself contains accelerometers (ACC) and gyroscopes (GYR), which measured movement data at a sampling rate of 25 Hz. The EEG SD electrode placement depended on the patient's medical history and is based on the seizure type and onset. When the seizures were suspected to originate from the left hemisphere, two electrodes were placed on the left side and one on the right side, forming one left same-side channel and one cross-head channel. Analogously, if seizures were suspected to originate from the right hemisphere, the same-side channel was derived from two electrodes placed behind the right ear. The dataset includes patients who were suspected to have generalized seizures (but had focal seizures) as well, and in this case, the cross-head channel was non-existent and replaced by an additional lateral channel by using two electrodes on each ear. ### Dataset contents The complete dataset contains around 11 640 hours of wearable data. Four different modalities were recorded for most participants: bte-EEG, ECG, EMG and movement data. All participants' data within the dataset contain wearable bte-EEG. In 3\% of the dataset, ECG, EMG and movement data were not included due to technical failures or errors in the setup. In total, 886 focal seizures were recorded with the wearable device. The mean duration of the recorded seizures was 58 seconds, ranging between 3 seconds and 16 minutes. The majority of the seizures were focal aware (FA) and focal impaired awareness (FIA), with 317 and 393 occurrences, respectively. From the remaining seizures, 55 were focal-to-bilateral tonic clinic (FBTC), 12 were focal with unclear awareness status, 2 were subclinical focal seizures and 93 had unknown or unreported onset. There was a predominance of seizures with onset on the left hemisphere (44\%). In 12\% of the seizures, the onset was located in the right hemisphere, 1\% had a bilateral onset and in 43\% of the seizures the onset was unclear. Regarding localization, the seizure onsets were distributed over the central, frontal, temporal, occipital, parietal and insula lobes, with a predominance of temporal lobe seizures (30\%). Several seizures recorded could not be paired with a clear onset lobe (26\%).# 自述文件 本数据集为SeizeIT2数据集的脑成像数据结构（Brain Imaging Data Structure，BIDS）兼容版本，其重构了文件组织结构以符合BIDS规范，具体调整如下： - 元数据已按照BIDS规范进行整理； - EDF文件中的数据包含使用Sensor Dot设备采集的可穿戴式脑电图（electroencephalogram, EEG）、心电图（electrocardiogram, ECG）、肌电图（electromyogram, EMG）及运动数据； - 注释文件已格式化为兼容BIDS-score的TSV文件。 ### 联系人 本数据集由[Miguel Bhagubai]([e-mail])与[Christos Chatzichristos]([e-mail])发布。 ## 概览 ### 项目名称 SeizeIT2数据集 ### 项目执行年份 2024年 ### 数据集描述 SeizeIT2项目（clinicaltrials.gov编号：NCT04284072）是一项多中心前瞻性研究，旨在验证Sensor Dot设备在成人及儿科癫痫患者中的应用效果。入组受试者需具备难治性癫痫病史，且因术前评估需求入住癫痫监测单元（Epilepsy Monitoring Unit, EMU）接受长期视频脑电图（video EEG, vEEG）监测。排除标准包括存在皮肤疾病或过敏反应导致无法放置电极与黏合剂的患者，以及植入神经刺激器、心脏起搏器等植入式设备的患者。所有受试者均签署了书面知情同意书。数据采集始于2020年1月10日，终止于2022年6月30日。本研究已获得鲁汶大学医院伦理委员会批准（批准编号：S63631，ClinicalTrials.gov编号：NCT04284072），数据的匿名化与共享也经同一委员会批准（S67350——修正案1）。 本数据集纳入了来自欧洲5家不同癫痫监测单元的125名患者（其中女性51名，占比41%），这5家机构分别为：比利时鲁汶大学医院、德国弗莱堡大学医学中心、德国亚琛工业大学医院、瑞典卡罗林斯卡大学医院以及葡萄牙科英布拉大学医院。仅鲁汶大学医院一家纳入了儿科患者。本数据集仅包含局灶性癫痫患者的数据，且这些患者在监测期间出现过一次或多次癫痫发作。 ## 研究方法 受试者使用所在中心的标准vEEG监测设备进行记录，脑电图电极按照10-20系统或国际临床神经生理学联合会的25电极阵列进行放置。Sensor Dot（SD）设备与vEEG同步采集可穿戴式数据。该设备尺寸为24.5×33.5×7.73 mm，重量约6.3克，采样频率为250 Hz，续航时长约24小时。 本次研究使用了两台录制设备：一台通过贴片固定于患者上背部，连接电极置于耳后乳突骨处，用于采集可穿戴式脑电图（bte-EEG）；另一台固定于左侧胸部，通过两根电极延伸至左下胸廓与左侧胸骨旁第四肋间隙以采集心电图数据，另外两根电极延伸至左侧三角肌以采集肌电图数据。设备本体内置加速度计（accelerometer, ACC）与陀螺仪（gyroscope, GYR），以25 Hz的采样率采集运动数据。 可穿戴式脑电图的电极放置方案取决于患者病史，结合癫痫发作类型与起源部位确定：若怀疑癫痫起源于左侧大脑半球，则在左侧放置2枚电极、右侧放置1枚电极，分别构成同侧通道与跨颅通道；同理，若怀疑起源于右侧大脑半球，则同侧通道由右侧耳后的2枚电极构成。本数据集同时纳入了被怀疑为全面性发作但实际为局灶性发作的患者，此类患者无跨颅通道，取而代之的是在双耳各放置2枚电极以构建额外的侧方通道。 ### 数据集内容 完整数据集包含约11640小时的可穿戴式数据。多数受试者采集了四种模态的数据：可穿戴式脑电图（bte-EEG）、心电图、肌电图及运动数据，所有受试者的数据均包含bte-EEG。由于设备故障或设置错误，约3%的数据集未包含心电图、肌电图及运动数据。本次研究通过可穿戴设备共记录到886次局灶性癫痫发作，单次发作平均持续时长为58秒，时长范围为3秒至16分钟。其中大部分发作为局灶性清醒发作（FA）与局灶性意识障碍发作（FIA），分别记录到317次与393次。剩余发作类型包括：55次局灶性继发双侧强直阵挛发作（FBTC）、12次意识状态不明的局灶性发作、2次亚临床局灶性发作，以及93次起病部位未知或未报告的发作。左侧大脑半球起病的发作占比最高（44%），右侧半球起病占12%，双侧起病占1%，剩余43%的发作起病部位不明。就发作定位而言，癫痫起病分布于中央、额叶、颞叶、枕叶、顶叶及脑岛，其中颞叶起源的发作占比最高（30%），另有26%的发作无法匹配明确的起病脑叶。

搜集汇总

背景与挑战

背景概述

SeizeIT2数据集是一个BIDS兼容的公开神经科学数据集，包含125名局灶性癫痫患者的可穿戴多模态生理数据，如EEG、ECG、EMG和运动数据，由欧洲多个医疗中心在2020年至2022年间收集。该数据集旨在验证Sensor Dot设备，记录了886次癫痫发作事件，平均持续58秒，主要用于癫痫监测和发作检测研究。