SD大鼠

白色封闭群大鼠，1925年Robert W.Dawley将一只杂种雄性和一只雌性Wistar大鼠交配，得到该品系。1950年CRL从Sprague Dawley Inc.引入该品系，形成Charles River SDTM，1955年进行剖腹产形成现在CD核心群，1991年从中选择8个种群形成IGS基础种群，1997年剖腹产得到隔离器种群。被毛白色，头部狭长，尾长接近身长，产仔多,生长发育较Wistar快，抗病能力尤以对呼吸系统疾病的抵抗力强，自发肿瘤率低，对性激素感受性高。10周龄雄鼠体重可达300～400g，雌鼠体重可达180～270g。常用作营养学、内分泌学和毒理学等方面的研究。White outbred Sprague Dawley rats: In 1925, Robert W. Dawley developed this strain by crossing a hybrid male rat with a female Wistar rat. In 1950, Charles River Laboratories (CRL) introduced this strain from Sprague Dawley Inc., establishing the Charles River SDTM colony. In 1955, cesarean section was performed to establish the current CD core colony. In 1991, 8 subcolonies were selected from this colony to form the IGS foundation colony, and an isolator-reared colony was derived via cesarean section in 1997. This strain features white coat, slender head, tail length close to body length, high litter size, faster growth rate compared to Wistar rats, strong disease resistance particularly against respiratory diseases, low spontaneous tumor incidence, and high sensitivity to sex hormones. At 10 weeks of age, male rats can reach 300–400 g in body weight, while female rats weigh 180–270 g. They are commonly used in research fields including nutrition, endocrinology, toxicology and other related disciplines.

搜集汇总

背景与挑战

背景概述

该数据集详细介绍了SD大鼠（Sprague Dawley）这一白色封闭群实验动物资源，包括其起源自1925年通过Wistar大鼠杂交培育的历史发展过程、生理特征如生长发育快、抗病能力强、自发肿瘤率低，以及广泛应用于营养学、内分泌学和毒理学研究。数据集由国家啮齿类实验动物资源库管理，通过线下方式完全共享，为科研人员提供重要的实验动物信息支持。