The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic resistant endospores that contribute to relapsing and recurrent infections. Des

NIAID Data Ecosystem20

Metabolic Imbalance and Sporulation in an Isocitrate Dehydrogenase Mutant of Bacillus subtilis

细菌孢子形成调控

代谢物积累研究

A Bacillus subtilis mutant with a deletion in the citC gene, encoding isocitrate dehydrogenase, the third enzyme of the tricarboxylic acid branch of the Krebs cycle, exhibited reduced growth yield in

PubMed Central10

Genes required for aerial growth, cell division, and chromosome segregation are targets of WhiA before sporulation in Streptomyces venezuelae.. Genes required for aerial growth, cell division, and chromosome segregation are targets of WhiA before sporulation in Streptomyces venezuelae.

细菌孢子形成调控

细胞分裂基因网络

WhiA is a highly unusual transcriptional regulator related to a family of eukaryotic homing endonucleases. WhiA is required for sporulation in the filamentous bacterium Streptomyces, but WhiA homologu

NIAID Data Ecosystem20

decoupleR: Ensemble of computational methods to infer biological activities from omics data

基因调控网络

磷酸化蛋白质组学分析

We used decoupleR to evaluate the performance of individual methods by recovering perturbed transcription factors (TFs) from a curation of single-gene perturbation experiments (Holland et al., 2020).

NIAID Data Ecosystem20

Phosphorylated aspartate in the crystal structure of the sporulation response regulator, Spo0A

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