Transciptome analysis of TP63 regulated pathways in HNSCC. Transciptome analysis of TP63 regulated pathways in HNSCC

Purpose: To identify TP63 expression regulated pathways in HNSCC Methods: A recombinant lentivirus encoding either NS shRNA or TP63 shRNA was introduced into a HNSCC cell line, FaDu. SCCs were gene generated by implanting either FaDu-NS shRNA (n=3) or FaDu-TP63 shRNA into the tongue of athymic nude mice. Tongue SCCs harvested at the end of study were used for transcriptome analysis Overall design: Identification of differentially expressed transcripts in TP63 knockdown SCCs compared to NS shRNA SCCs