CpG island reconfiguration for the establishment and synchronization of Polycomb functions upon exit from naïve pluripotency
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Trichostatin A does not correct specific errors of somatic cell nuclear transfer on the transcriptomic level; highlighing the non-random nature of oocyte-mediated reprogramming errors.
Bovine cloned and IVF blastocysts at day 7 were collected and used for comparative transcriptomics. A potent histone deacetylase inhibitor, Trichostatin A (TSA), was used to understand the effect of
NIAID Data Ecosystem60
AKT signaling promotes epigenetic reprogramming via upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation
Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular proliferation, survival, and tumorigenesis as well as cellular reprogramming including generation of induced pluripotent stem ce
NIAID Data Ecosystem50
PGC reversion to pluripotency involves erasure of DNA methylation from imprinting control centers followed by locus-specific re-methylation. Mus musculus
Primordial germ cells (PGCs) are fate restricted to differentiate into gametes in vivo. However when removed from their embryonic niche PGCs undergo reversion to generate pluripotent embryonic germ ce
NIAID Data Ecosystem40
Single Cell Sequencing Identifies Key Epigenetic Regulators in Nuclear Transfer Mediated Reprogramming [ChIP-seq]
Differentiated cell can be reprogrammed into totipotent embryo through somatic cell nuclear transfer (SCNT). However, this process is highly inefficient and most cloned embryos arrest at certain devel
NIAID Data Ecosystem50
Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential.
NIAID Data Ecosystem50
