Transcription profiling of mouse mutant for microRNA-96 vs. wildtype mice to identify potential targets

The Diminuendo mouse mutant strain displays progressive deafness and carries a mutation in the gene mmu-mir-96, a microRNA. We carried out a microarray analysis using RNA extracted from the organ of Corti from 4-day old mutant (n=6) and wildtype (n=6) mice to compare gene expression of both direct and indirect targets.Diminuendo小鼠突变品系表现出进行性听力损失，其微小RNA（microRNA）基因mmu-mir-96携带突变。本研究使用从4日龄突变型（n=6）与野生型（n=6）小鼠的柯蒂氏器（organ of Corti）中提取的RNA开展微阵列分析，以对比直接靶标与间接靶标的基因表达情况。