<i>ACPY2</i> gene polymorphisms on cancer risk: a systematic review and meta-analysis

To provide a comprehensive account of the association of <i>ACYP2</i> gene polymorphisms with susceptibility to cancer. A literature search for eligible candidate gene studies published before April 20, 2022 was conducted in the PubMed, Medline and Web of Science. The following combinations of main keywords were used: (ACYP2 OR acylphosphatase 2) AND (polymorphism OR mutation OR variation OR SNP OR genotype) AND (cancer OR tumor OR neoplasm OR malignancy OR carcinoma OR adenocarcinoma). Potential sources of heterogeneity were sought out via subgroup and sensitivity analysis. Publication bias were also estimated. Overall, a total of 10 articles with 5,230 cases and 5,086 controls for thirteen polymorphisms of <i>ACYP2</i> gene were enrolled. We found that <i>ACYP2</i> rs11125529, rs11896604, rs12615793, rs17045754, rs6713088, rs843645, rs843706, rs843711 and rs843752 were correlated with an increased risk of cancer. However, we found that <i>ACYP2</i> rs12621038 might have less susceptibility to cancer. While for other polymorphisms, the results showed no significant association with cancer risk. <i>ACYP2</i> rs11125529, rs11896604, rs12615793, rs17045754, rs6713088, rs843645, rs843706, rs843711 and rs843752 are associated with cancer risk. <i>ACYP2</i> rs12621038 polymorphism is inversely associated with cancer risk.

本研究旨在全面阐明ACYP2基因（酰基磷酸酶2）多态性与癌症易感性的关联。我们于2022年4月20日前，在PubMed、Medline及Web of Science数据库中检索符合纳入标准的候选基因研究文献，采用如下主关键词组合进行检索：（ACYP2 OR 酰基磷酸酶2）AND（多态性 OR 突变 OR 变异 OR 单核苷酸多态性（SNP） OR 基因型）AND（癌症 OR 肿瘤 OR 赘生物 OR 恶性肿瘤 OR 癌 OR 腺癌）。本研究通过亚组分析与敏感性分析探寻潜在的异质性来源，并对发表偏倚进行了评估。最终共纳入10篇相关文献，涉及ACYP2基因的13个多态性位点，包含5230例病例与5086例对照。研究结果显示，ACYP2基因rs11125529、rs11896604、rs12615793、rs17045754、rs6713088、rs843645、rs843706、rs843711及rs843752位点与癌症风险升高显著相关；而ACYP2基因rs12621038位点则可能降低癌症易感性。对于其余多态性位点，本研究未发现其与癌症风险存在显著关联。综上，ACYP2基因rs11125529、rs11896604、rs12615793、rs17045754、rs6713088、rs843645、rs843706、rs843711及rs843752位点与癌症风险相关；ACYP2基因rs12621038多态性位点与癌症风险呈负相关。

搜集汇总

背景与挑战

背景概述

该数据集是一个系统综述和荟萃分析，旨在评估ACYP2基因多态性与癌症风险的关联。基于10篇文献（5230例病例和5086例对照），研究发现多个ACYP2多态性（如rs11125529等）与癌症风险增加相关，而rs12621038则与风险降低相关，为癌症遗传易感性研究提供了关键证据。