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WDR5 facilitates cholangiocarcinoma metastasis and EMT by promoting HIF-1a accumulation via directly interaction with c-Myc and HDAC2-PHD2 axis

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NIAID Data Ecosystem2026-03-12 收录
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WDR5 was an important co-factor for c-Myc-induced transcriptional activation and malignant progression. We analyzed the differentially expressed genes in scramble and shWDR5 QBC-939 cells. Overall design: QBC-939 cells were stably transfected with scramble shRNA(scr) and WDR5-knockdown shRNA(sh) and subjected to differential gene expression studies by RNA-seq

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2021-02-25
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