This research investigates how the cell adhesion molecule CHL1 and the tumor suppressor DLC1 regulate neural development and contribute to neurodegenerative disease mechanisms. The study explores mole
Brains are highly metabolically active organs, consuming 20% of a person’s energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases. A
Nuclear RNA foci are often associated with mis-regulation of RNA processing in repeat expansion diseases. Here we report transcriptomic analysis of mice expressing expanded G4C2 repeats, the most comm
This study aimed to compare global miRNA expression profiles using miRNA-seq in C. elegans strains carrying single-copy insertions of 0 or 99 CGG repeats driven by a pan-neuronal promoter. To further
