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Xenobiotic-responsive Nuclear Receptors in Transcriptional Effects Upon Perfluoroalkyl Acid Exposure in Diverse Species

Alliance of Genome Resources2026-08-01 收录

全氟烷基酸毒理

核受体转录调控

数据链接：

https://www.ncbi.nlm.nih.gov/gds/?term=GSE14712 数据链接链接失效反馈

官方服务：

资源简介：

Keywords: gene expression/microarray

关键词：基因表达（gene expression）/微阵列（Microarray）

应用场景：

肝脏糖异生

核受体转录调控

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes a committed and rate-limiting step in hepatic gluconeogenesis, and its activity is tightly regulated to maintain blood glucose levels within normal

NIAID Data Ecosystem40

Transcriptional Silencing Is Defined by Isoform- and Heterodimer-Specific Interactions between Nuclear Hormone Receptors and Corepressors

核受体转录调控

蛋白质相互作用

Nuclear hormone receptors are ligand-regulated transcription factors that play critical roles in metazoan homeostasis, development, and reproduction. Many nuclear hormone receptors exhibit bimodal tra

PubMed Central30

Crystal structure of Nurr1 binding to NBRE

DNA复合物

核受体转录调控

Crystal structure of Nurr1 binding to NBRE Descriptor: DNA (5'-D(*CP*CP*GP*AP*AP*AP*AP*GP*GP*TP*CP*AP*TP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*AP*TP*GP*AP*CP*CP*TP*TP*TP*TP*CP*GP*G)-3'), Nuclear receptor

Protein Data Bank Japan2023-11-29 更新20

The IR-1 at −291/−279 is required for 9cRA-, but not for CDCA-mediated induction of the human SHP promoter.

核受体转录调控

启动子分析

DLD-1 cells were transfected with hFXR and hRXRα expression plasmids and various hSHP promoter constructs as indicated. Cells were treated with or without 100 µmol/L CDCA and/or 1 µmol/L 9cRA. The syn

NIAID Data Ecosystem40

PSF Is a Novel Corepressor That Mediates Its Effect through Sin3A and the DNA Binding Domain of Nuclear Hormone Receptors

核受体转录调控

基因沉默机制

Members of the type II nuclear hormone receptor subfamily (e.g., thyroid hormone receptors [TRs], retinoic acid receptors, retinoid X receptors [RXRs], vitamin D receptor, and the peroxisome prolifera

PubMed Central20

Xenobiotic-responsive Nuclear Receptors in Transcriptional Effects Upon Perfluoroalkyl Acid Exposure in Diverse Species

资源简介：

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