LncRNA and mRNA expression data from TMZ-resistant cell line. Homo sapiens

Glioblastoma multiforme (GBM) is the most common and lethal malignant primary brain tumor. Temozolomide (TMZ) is a promising chemo-therapeutic agent to treat GBM. However, resistance to TMZ develops quickly with a high frequency. The mechanisms underlying GBM cells’ resistance to TMZ are not fully understood. Long non-coding RNAs (lncRNAs) are aberrantly expressed in many cancers and are highly involved in their pathogenesis including drug-resistence. In order to systematically study the role of lncRNAs in GBM cells' resistence to TMZ , we built gene expression profiles of TMZ-resistant cell line and TMZ-sensitive cell line using lncRNA and mRNA gene expression microarrays. Overall design: TMZ-resistant cell line and TMZ-sensitive cell line were used for RNA extraction and hybridization on microarrays. We sought to study the expression profiles of lncRNA and mRNA in GBM cell lines and to find potential core genes in the drug-resistance of this high malignant lethal disease.