Dual Inhibition of the Essential Protein Kinases A and B in Mycobacterium tuberculosis
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Dual Inhibition of the Essential Protein Kinases A and B in Mycobacterium tuberculosis Descriptor: 3-methyl-1-(2-methylpropyl)butyl 4-O-beta-L-gulopyranosyl-beta-D-glucopyranoside, 5-{5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}thiophene-2-sulfonamide, Serine/threonine-protein kinase PknA Authors: Zuccola, H.J. Deposit date: 2017-09-20 Release date: 2018-02-14 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions. ACS Med Chem Lett, 8, 2017
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2017-09-20
