Changes in miRNA expression during wound healing in mouse aged skin. Mus musculus

To identify the candidate miRNAs that might compromise wound healing and contribute to the age-associated delay in wound repair, global miRNA profiling was performed in mouse back telogen skin of young (8-week-old) and aged (2-year-old) animals. Overall design: A full-thickness 3 mm wound was introduced by punch biopsy onto mouse back skin at the telogen stage of the hair cycle. Skin samples were collected on days 0, 3, 5, and 7 after wounding and were snap-frozen in liquid nitrogen.