Disrupting Mechanotransduction Promotes Regenerative Phenotypes in Human Cells
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资源简介：
We quantify the effects of FAK inhibition on three-dimensional (3D) cultured human fibroblasts at the cellular and transcriptomic level using single cell RNA-sequencing. We demonstrate that mechanical stress induces pro-fibrotic fibroblast differentiation fates in large organisms, which can effectively be averted by FAK inhibition, which induces discrete fibroblast clusters that promote wound regeneration.
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Stanford University创建时间：
2022-02-20
