The role of Clk3 in the development of heart hypertrophy. The role of Clk3 in the development of heart hypertrophy

We used RNA-seq technology to characterise the extent of transcriptional response to transverse aortic compression (TAC) in mouse models, both in wild type and in Clk3-knocked down animals. We thereby provide an extensive characterization of the changes occurring at the genome-wide levels, including isoforms switches and splicing patterns. Overall design: Examination of gene expression levels in the heart of wild type and Clk3 KO mice, after TAC.