CalliSpheres microspheres for the treatment of liver metastases from colorectal cancer: the effect of irinotecan on the HIF-1a pathway and its anti-tumor effect

Interventions: Group A:Callispheres microspheres were loaded with 100 mg irinotecan for the embolization, and surgical resection of metastases at different time points;Group B:Callispheres microspheres were loaded with 200 mg irinotecan for the embolization, and surgical resection of metastases at different time points;Group C:Callispheres microspheres were loaded with 400 mg irinotecan for the embolization, and surgical resection of metastases at different time points;Control group:After the examination is completed, the liver metastases are directly removed. Primary outcome(s): Irinotecan concentration in the tumor tissue;Plasma irinotecan concentration Study Design: Parallel