From those compounds exhibiting IC50 50 Giardia trophozoites in the benchmark screening (see in Fig 3) exact dose responses were determined (values highlighted in green). PDE activity assays were done
Schistosomiasis is a debilitating neglected tropical disease, caused by flatworms of Schistosoma genus. The treatment relies on a single drug, praziquantel (PZQ), making the discovery of new compounds
