An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses

NIAID Data Ecosystem2026-03-08 收录

黏膜免疫调节

Th17细胞炎症通路

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA289125 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

创建时间：

2015-07-07

Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection

黏膜免疫调节

上皮-间质相互作用

Intraepithelial T cells (IET) provide surveillance of the intestinal epithelium, but little is known about how epithelial-derived signals regulate IET. Analyzing mice with a deficiency for the herpes

NIAID Data Ecosystem70

RNAseq of sorted a4b7+CCR9+ CD4+ Teff cells from human PBMC cultured in 10uM CITCO or DMSO control for 24 hours

黏膜免疫调节

小肠克罗恩病治疗机制

Bile acids (BAs) are a fundamental class of lipid emulsifying metabolites that are synthesized by hepatocytes, important for fat-soluble vitamin absorption, and maintained in vivo through enterohepati

NIAID Data Ecosystem20

Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses. Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses

黏膜免疫调节

浆细胞迁移

Krüppel-like factor 2 (KLF2) is a potent regulator of lymphocyte differentiation, activation and migration. However, its functional role in adaptive and humoral immunity remains elusive. Therefore, by

NIAID Data Ecosystem20

Activated Human Nasal Epithelial Cells Modulate Specific Antibody Response against Bacterial or Viral Antigens

黏膜免疫调节

抗体反应

Nasal mucosa is an immune responsive organ evidenced by eliciting both specific local secretory IgA and systemic IgG antibody responses with intra-nasal administration of antigens. Nevertheless, the r

NIAID Data Ecosystem30

T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium

黏膜免疫调节

宿主-微生物相互作用

The regulation of mucosal immune function is critical to host protection from enteric pathogens but is incompletely understood. The nervous system and the neurotransmitter acetylcholine play an integr

Figshare2019-04-23 更新20

An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses

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