RNAseq of human brain cell lines

In the murine brain, perivascular fibroblasts were recently identified as a novel potential constituent of the BBB. Here we present the existence of human cells, that could be the equivalent to the murine brain perivascular fibroblasts. Using RNA sequencing, we here show a similar transcriptomic profile of cultured human brain cells and murine perivascular fibroblasts. These data open up for new hypotheses on cell types involved in human CNS diseases. we performed bulk-RNA sequencing of 18 human cell lines and compared their transcriptional profiles with our previously published adult murine brain vascular cells