NAMPT-mediated NAD+ salvage is essential for mitochondrial function and swelling, muscle fiber integrity and premature survival. NAMPT-mediated NAD+ salvage is essential for mitochondrial function and swelling, muscle fiber integrity and premature survival

Skeletal muscle gene expression changed exponential over time in response to NAMPT deletion Overall design: Gene expression in gastrocnemius muscle of wildtype and skeletal muscle specific Nampt knockout mice at 2, 4, 6, and 8 weeeks of age.