The_role_of_the_large_conjugative_Klebsiella_pneumoniae_plasmids_in_the_decemination_of_carbapenem_resistance_in_infection

Antimicrobial chemotherapy remains the cornerstone in the treatment of patients with severe, life threatening, bacterial infection. A delay in the administration of appropriate antibiotics is devastating.The rapid global expansion of antimicrobial resistance, particularly in Gram-negative bacteria, threatens to make antibiotic treatment ineffective (Rice, 2008). This PhD project explores the interaction between the important hospitalacquired pathogen Klebsiella pneumoniae and the emerging threat of carbapenem antibiotic resistance. Klebsiella pneumoniae commonly causes hospital-acquired infection that increasingly exhibits an antibiotic resistant phenotype (Pitout, et al., 2015).