Hif-1alpha deletion leads to adverse treatment efficacy in a mouse model of MLL-AF9 driven AML
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This report explores the effect of Hif-1alpha deletion, using a conditional mouse model, together with standard chemotherapy regimen to evaluate leukemia stem cell (LSC) targeting in a murine model of MLL-AF9 driven acute myeloid leukemia (AML). This study reveals that Hif-1alpha-deleted leukemias displayed a faster disease progression after chemotherapy.
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BMC创建时间：
2022-02-20
