Heat Shock Proteins: Protection and Potential Biomarkers for Ischemic Injury of Cardiomyocytes After Surgery

Abstract The heat shock proteins are endogenous proteins with the ability to act as molecular chaperones. Methods that provide cell protection by way of some damage can positively influence the results of surgery. The present review summarizes current knowledge concerning the cardioprotective role of the heat shock proteins as occurs in heart damage, including relevant information about the stresses that regulate the expression of these proteins and their potential role as biomarkers of heart disease.摘要 热休克蛋白（heat shock proteins）是一类可充当分子伴侣的内源性蛋白质。通过诱导适度损伤以实现细胞保护的干预策略，可对手术预后产生积极影响。本综述总结了当前关于热休克蛋白在心脏损伤中发挥心脏保护作用的相关研究成果，其中涵盖了调控该类蛋白表达的各类应激因素，以及其作为心脏疾病生物标志物的潜在价值。