HGP, hepatic glucose production; FPI, fasting plasma insulin. Model 1, adjusted for, age, sex, and body mass index; Model 2, adjusted for, age, sex, body mass index, and total fat mass. aP<0.05, bP<0.
‡Abbreviations. AUC0-∞: Area under the concentration-time curve from zero to infinity; Cmax: actual maximum concentration observed after drug administration; Tmax: time of maximum drug concentration.
a The CL and V parameters are conditioned on oral bioavailability and fraction of parent changed to metabolite.CLd = distribution clearance; CLt = first-order clearance from the central compartment; C