Backbone Dialkylation in Peptide Hairpins: Natural Backbone Prototype

NIAID Data Ecosystem2026-05-02 收录

化学修饰

药物分子设计

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Backbone Dialkylation in Peptide Hairpins: Natural Backbone Prototype

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2024-10-16

Regioselective Synthesis of Functionalized 3- or 5‑Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles

含氟杂环合成

化学修饰

A facile synthetic route toward either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an additional functionalization site was developed and applied on a multigram scale. The elabo

NIAID Data Ecosystem50

GUACAMOL project samples coordinates

药物分子设计

分子构象分析

Coordinates of the samples collected in the framework of the GUACAMOL project within Sébastien Mirolo PhD.

Figshare2026-02-13 更新40

Synthesis of 1,4-Benzodiazepine-3,5-diones

杂环化合物合成

药物分子设计

Even though benzodiazepines have a strong position in medicinal chemistry, very few synthetic routes to 1H-1,4-benzodiazepine-3,5(2H,4H)-diones have ever been published and the claimed products have o

NIAID Data Ecosystem30

Design and Synthesis of Backbone-Fused, Conformationally Constrained Morpholine-Proline Chimeras

药物分子设计

肽类模拟物

We report the synthesis of two novel bridged morpholine-proline chimeras 4 and 5, which represent rigid conformationally locked three-dimensional structures wherein the lone pairs of electrons on oxyg

NIAID Data Ecosystem50

BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P

药物分子设计

蛋白质-配体相互作用

BRD4 Bromodomain 1 in complex with multi-action inhibitor SRX3212P Descriptor: 7-[7-oxo-5-(piperazin-1-yl)-7H-thieno[3,2-b]pyran-3-yl]-N-[(pyridin-3-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxami

Protein Data Bank Japan2023-10-18 更新30

Backbone Dialkylation in Peptide Hairpins: Natural Backbone Prototype

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