RNA-seq and m6A-seq were used to analysis RNA m6A methylation between hypertrophic and normal mouse hearts

In this experiment, we constructed a mouse myocardial hypertrophy model through transverse aortic constriction (TAC) to further explore the relationship between m6A modification and myocardial hypertrophy, MeRIP-seq and RNA-seq were performed to identify genes with differences m6A modification or expression in transcriptome profile. Comparative gene expression profiling analysis of RNA-seq data and examing the m6A modification between hypertrophic and normal mouse hearts(sham and TAC).