Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model

Reduced representation bisulfite sequencing was carried out on male mouse (C57BL/6) liver tissue DNA aged 4 or 24 months, to map sites in the liver genome undergoing epigenetic aging. The purpose of this study was to investigate the effects of epigenetic aging on xenobiotic metabolism and transport genes.