An Annotated Corneal Confocal Microscopy Dataset for Nerve Segmentation and Clinical Characterization

Cite the article Qiao, Q., Cao, J. & Hou, X. An Annotated Corneal Confocal Microscopy Dataset for Nerve Segmentation and Clinical Characterization. Sci Data (2026). https://doi.org/10.1038/s41597-026-07418-6 User Guide The uncompressed dataset consists of two folders and a Microsoft Excel file, named “images”, “annotations”, and “data.xlsx”, respectively. The first two folders contained the original CCM images and their corresponding segmentation masks, each comprising 410 PNG images. Each original image has a corresponding mask with an identical filename. The “re-annotations” folder includes 10 images selected from each of Set1 and Set2, which were re-annotated by Annotator 2 and Researcher 2. The filenames are prefixed with a five-digit code following the SPPII pattern: the first digit (S) indicates the set number (1 or 2); the second and third digits (PP) represent the participant number within the set, padded with a leading zero if necessary; and the fourth and fifth digits (II) denote the image number for that participant, also zero-padded when needed. For example, “25104.png” refers to the fourth image (04) of Participant 51 in Set2. Clinical and demographic information are organised in the Excel file “data.xlsx”, which comprises two distinct sheets. The “Subjects” sheet details information at the subject level, whereas the “Images” sheet provides data at the image level, enabling direct mapping between images and their corresponding clinical data. A comprehensive description of all the columns in both sheets is provided in Table. Table. Clinical and demographic data associated with the cohort of examined subjects. Parameter Explanation ID Global identifier Filename The filename of the image Set ID Set identifier Subject ID Subject identifier within the Set Image ID Image identifier within the Subject Gender Sex (1 = male, 2 = female) Age Age at examination (years) Healthy Subject diagnosis information (1 = healthy, 0 = diabetic) Course Duration of diabetes from first diagnosis to examination (years) Height Height (cm) Weight Weight (kg) SBP Systolic blood pressure (mmHg) DBP Diastolic blood pressure (mmHg) FBG Fasting blood glucose (mmol/L) PBG 2 hour postprandial blood glucose (mmol/L) HBA1C Glycated hemoglobin (%) C-Peptide Fasting C-peptide (ng/mL) RBC Red blood cell count (10^12/L) Hb Hemoglobin concentration (g/L) AST Aspartate aminotransferase (U/L) ALT Alanine aminotransferase (U/L) CRE Creatinine (µmol/L) TC Total cholesterol (mmol/L) TG Triglycerides (mmol/L) HDL High density lipoprotein (mmol/L) LDL Low density lipoprotein (mmol/L) UACR Urine albumin-to-creatinine ratio (mg/g) Folic Acid Folic acid (ng/mL) VB12 Vitamin B12 (ng/mL)