The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Characterization of genes specifically expressed in mouse primary quiescent hepatic stellate cells (HSC) compared to the whole liver by RNA-sequencing and single cell RNA sequencing as well as effect of UDP-glucose treatment on mouse primary HSC. Bulk RNA sequencing of 13 samples: 4 quiescent HSC, 3 whole liver, 3 cultured-HSC untreated, 3 cultured HSC treated with UDP-glucose for 24h. Single cell RNA sequencing of normal untreated liver.本数据集通过RNA测序（RNA-sequencing）与单细胞RNA测序（single cell RNA sequencing），解析小鼠原代静息态肝星状细胞（hepatic stellate cells, HSC）相较于全肝组织的特异性表达基因特征，并研究尿苷二磷酸葡萄糖（UDP-glucose）处理对小鼠原代HSC的影响。数据集包含13个样本的批量RNA测序数据：其中4份为静息态HSC样本、3份为全肝组织样本、3份为未处理的培养HSC样本，另有3份经尿苷二磷酸葡萄糖处理24小时的培养HSC样本。此外还包含正常未处理肝脏的单细胞RNA测序数据。