Gene expression profiling in Wistar male rat left ventricle with chronic and severe aortic valve regurgitation

Aortic valve regurgitation (AR) imposes a severe volume overload to the left ventricle (LV) which results in dilation, eccentric hypertrophy and eventually loss of function. Little is known about the impact of AR on LV gene expression. We therefore conducted a gene expression profiling study in the LV of male Wistar rats with chronic (9 months) and severe AR.主动脉瓣反流（Aortic valve regurgitation, AR）会对左心室（left ventricle, LV）造成严重的容量负荷过载，进而引发心室扩张、离心性肥厚，最终导致心功能丧失。目前学界对主动脉瓣反流影响左心室基因表达的相关机制尚了解有限。因此，本研究针对慢性（9月龄）重度主动脉瓣反流的雄性Wistar大鼠的左心室开展了基因表达谱分析研究。