KRasG12C ligand complex
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KRasG12C ligand complex Descriptor: 1-[(4~{a}~{R})-8-(2-chloranyl-6-oxidanyl-phenyl)-7-fluoranyl-9-prop-1-ynyl-1,2,4,4~{a},5,11-hexahydropyrazino[2,1-c][1,4]benzoxazepin-3-yl]propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Phillips, C, Breed, J. Deposit date: 2022-09-29 Release date: 2023-07-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.11 Å) Cite: Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration. J.Med.Chem., 66, 2023
创建时间：
2022-09-29
