Ontogeny of Pulmonary Interstitial Macrophages Regulates Allergic Asthma

NIAID Data Ecosystem2026-05-02 收录

肺部免疫细胞发育

哮喘病理机制

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https://www.ncbi.nlm.nih.gov/sra/SRP476466 数据链接链接失效反馈

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Single-cell RNA-seq (Drop-seq platform) to determine the impact of LPS pre-exposure and macrophage ontological alterations on HDM allergic responses

创建时间：

2024-11-27

Data_Sheet_1_Th2-TRMs Maintain Life-Long Allergic Memory in Experimental Asthma in Mice.pdf

哮喘病理机制

组织驻留记忆T细胞

Allergic asthma is a chronic inflammatory remitting-relapsing disease affecting the airways. Long-lived allergen-specific memory CD4+ T helper 2 (Th2) cells in mice persist in lungs for more than 2 ye

NIAID Data Ecosystem110

RCT to determine whether increased fruit and vegetable intake reduces asthma symptoms and microbiology in children with asthma

儿童哮喘饮食干预

哮喘病理机制

Background: Fruit and vegetables contain many anti-inflammatory and antioxidant nutrients which may be protective in asthma, with evidence showing increased intake is inversely associated with wheeze

NIAID Data Ecosystem40

Arylhydrocarbon receptor and the cytochrome P450 enzyme CYP1B1 prevent exacerbation of allergic airway inflammation. Arylhydrocarbon receptor and the cytochrome P450 enzyme CYP1B1 prevent exacerbation of allergic airway inflammation

哮喘病理机制

肺上皮免疫调控

Signaling via the arylhydrocarbon receptor (AhR) is thought to contribute to exacerbation of allergic asthma by anthropogenic pollution. The physiological role of AhR and its downstream targets CYP1 f

NIAID Data Ecosystem20

Data_Sheet_3_Interaction Between CD34+ Fibrocytes and Airway Smooth Muscle Promotes IL-8 Production and Akt/PRAS40/mTOR Signaling in Asthma.PDF

哮喘病理机制

mTOR信号通路

BackgroundThe circulating progenitor cells of fibroblasts (fibrocytes) have been shown to infiltrate the airway smooth muscle compartment of asthma patients; however, the pathological significance of

NIAID Data Ecosystem50

Murine lung transcripts during soluble egg antigen (SEA)-induced allergic asthma and bleomycin-induced pulmonary fibrosis in Wildtype, IL-13Ra1 and IL-13Ra2 deficient mice sensitized and challenged. Mus musculus

哮喘病理机制

肺纤维化分子通路

Transcriptional profiling of mouse lungs by comparing PBS and saline treated lungs with SEA and bleomycin treated lungs, respectively. Mice strains used in this study include wild type (C57BL/6), IL-1

NIAID Data Ecosystem20

Ontogeny of Pulmonary Interstitial Macrophages Regulates Allergic Asthma

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