Background Keratoacanthoma (KA) is a self-limiting epidermal tumor for which histopathological examination sometimes suggests malignancy. Based on inconsistent clinical views, KA can be regarded as bo
Tumor initiation is often linked to a loss of cellular identity. Transcriptional programs determining cellular identity are preserved by epigenetically-acting chromatin factors. Although such regulato
Epigenetic dysregulation is a hallmark of cancer and epigenetic therapies offer promising avenues to combat malignancies. The Hippo-YAP pathway, a key regulator of proliferation, apoptosis, and cell f
Analysis of PolI and H3K27me3 binding patterns by ChIP-seq in mouse wildtype, premalignant and malignant Eµ-Myc cells. Overall design: ChIP-seq using anti-PolI or -H3K27me3 antibodies in mouse wildty
Recently, immune response modulation at the epigenetic level is illustrated in studies, but the possible function of RNA 5-methylcytosine (m5C) modification in cell infiltration within the tumor micro
