Crystal Structure of wild type EGFR in complex with TAK-788
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Crystal Structure of wild type EGFR in complex with TAK-788 Descriptor: Epidermal growth factor receptor, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate Authors: Skene, R.J, Lane, W. Deposit date: 2021-12-10 Release date: 2022-12-07 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.61 Å) Cite: Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer. Bioorg.Med.Chem.Lett., 80, 2022
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2021-12-10
