Avon Longitudinal Study of Parents and Children

ALSPAC is a longitudinal birth cohort study which enrolled pregnant women who were resident in one of three Bristol-based health districts in the former County of Avon with an expected delivery date between 1st April 1991 and 31st December 1992. Around 14,000 pregnant women were initially recruited. Detailed information has been collected on these women, their partners and subsequent children using self-completion questionnaires, data extraction from medical notes, linkage to routine information systems and from hands-on research clinics. Additional cohorts of participants have since been enrolled in their own right including fathers, siblings, children of the children and grandparents of the children. Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee (IRB00003312) and Local Research Ethics.

ALSPAC是一项纵向出生队列研究，招募了居住在原艾冯郡的布里斯托尔三个卫生区域内的孕妇，她们的预产期在1991年4月1日至1992年12月31日之间。最初共有约14,000名孕妇被招募。通过对这些妇女、她们的伴侣及后续子女进行自填问卷收集、从医疗记录中提取数据、与常规信息系统对接以及实地研究诊所的参与，收集了关于她们及其家庭的详细信息。此后，还招募了额外的参与者群体，包括父亲、兄弟姐妹、子女的子女以及子女的祖父母。研究获得了ALSPAC伦理和法律委员会（IRB00003312）以及当地研究伦理委员会的伦理批准。

搜集汇总

背景与挑战

背景概述

该数据集是英国一项重要的纵向出生队列研究，聚焦于1991年至1992年期间招募的孕妇及其家庭，收集了约14,000名参与者的生物样本、遗传数据和社会科学信息，旨在追踪多代人健康与发展。其特点包括跨学科数据整合（涵盖医学、遗传学和社会行为科学），以及由多家知名机构（如医学研究委员会和布里斯托尔大学）支持，但数据访问受限且需付费，适用于长期健康研究。