Regulation of intestinal immunity and tissue repair by enteric glia
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2023-10-03
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The neuropeptide neuromedin U directs eosinophils to promote epithelial cell differentiation and barrier immunity of the small intestine
In this work we show that neuromedin U receptor 1 (NMUR1)-mediated signaling programs SI eosinophils to support epithelial cell differentiation and barrier immunity. The global transcriptional profili
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Requirement of mitochondrial transcription factor A in interleukin-17-producing gdT cells to regulate the small intestine homeostasis and metabolism
Interleukin 17 (IL-17)-producing gamma delta T (gdT17) cells are one of the major cellular sources of IL-17 under the steady state and in disease. However, gdT17 cell metabolism and its role in tissue
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Regulation of intestinal immunity and tissue repair by enteric glia (Bulk gene expression analysis of small intestinal glia cells in naïve and H. poly-infected mice.). Regulation of intestinal immunity and tissue repair by enteric glia (Bulk gene expression analysis of small intestinal glia cells in naïve and H. poly-infected mice.)
Tissue maintenance and repair depend on the integrated activity of multiple cell types. Whereas the contributions of epithelial, immune and stromal cells in intestinal tissue integrity are well unders
NIAID Data Ecosystem20
Type 3 innate lymphoid cells direct goblet cell differentiation via the LT-LTβR pathway during Listeria infection
As a specialized subset of intestinal epithelial cells (IECs), goblet cells (GCs) play an important role during the antibacterial response via mucin production. However, the regulatory mechanisms invo
NIAID Data Ecosystem100
Pharmacological autophagy modulation bidirectionally regulates IL-17A and IL-22 production in intestinal ILC3 subsets of NEC mice
Experimental Design Core Objective: Flow cytometry was performed to evaluate the effects of pharmacological autophagy modulation (autophagy inhibition by 3-Methyladenine, autophagy activation by Rapam
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