糖醇片剂脆碎度的差异化检测分析数据

片剂的生产、运输等过程中不可避免地会受到震动或摩擦作用，这些因素可能造成片剂的碎片、顶裂、破裂等，影响应用。片剂脆碎度是反映片剂抗震耐磨能力的指标，也是片剂质量标准检查的重要项目，本数据可作为企业及消费者分析糖醇片剂酥脆度的重要参考。取若干片目标片剂。用吹风机吹去脱落的粉末，精密称重，置脆碎仪圆筒中，以计时状态启动转动10min后取出，同法除去粉末，精密称重，减失重量不得过1%，且不得检出断裂、龟裂及粉碎的片。本试验一般仅作1次。如减失重量超过1%时，可复检2次，3次的平均减失重量不得过1%，并不得检出断裂、龟裂及粉碎的片。并根据下列公式进行计算：（a-b)÷a×100=%脆碎度 式子中a为测试前片重 b为测试后片重

Vibrations and friction are unavoidable during the production, transportation and other processes of tablets, which may cause chipping, capping, cracking and other damages to the tablets and adversely affect their application. Tablet friability is an indicator reflecting the shock and wear resistance of tablets, and it is also a critical item in tablet quality standard inspection. This dataset can serve as an important reference for enterprises and consumers to analyze the friability of sugar alcohol tablets. Take a number of target tablets, blow off the detached powder with a hair dryer, accurately weigh them, place them in the cylinder of a tablet friability tester, start the rotation for 10 minutes in timing mode, take them out, remove the powder in the same way, and accurately weigh again. The weight loss shall not exceed 1%, and no cracked, crazed or crushed tablets shall be detected. This test is generally performed only once. If the weight loss exceeds 1%, two additional retests may be conducted, and the average weight loss of the three tests shall not exceed 1%, and no cracked, crazed or crushed tablets shall be detected. The friability is calculated using the following formula: (a - b) ÷ a × 100 = % Friability, where a is the tablet weight before the test and b is the tablet weight after the test.