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资源简介：
Off-target analysis of CRISPR genome editing
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创建时间：
2021-03-30
相关数据集
Escherichia coli strain:BL21-AI Raw sequence reads. Escherichia coli strain:BL21-AI
Investigation of off-target CRISPR spacer integration activity in E. coli.
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Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity with CHANGE-seq-BE [CHANGE-seq-BE for CBE targets]
To adapt and apply for cytosone base editors (CBEs), we perfomed CHANGE-seq-BE using eA3A-BE3 to target B2M, CBLB, CD7, CIITA and PDCD1 regions at different loci. CHANGE-seq-BE identified low frequenc
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Comparison_between_full_length_and_trancated_CRISPR_guide_RNAs
The CRISPR-Cas system is a new DNA-editing technology and promise potential in many applications such as genome engineering and genetic screening. One issues associsted with this technology is off-tar
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Additional file 2 of CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters
Source code of CRISPRspec and CRISPRoff. (TAR 12,511 kb)
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Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity [Cut&Tag]
While CRISPR/Cas9 holds therapeutic promise, broader application demands understanding complications in vast non-coding regions. We found that CRISPR/Cas9 can cause premature differentiation of neural
NIAID Data Ecosystem70
