Maternal obesity has sex dependent effects on liver transcriptome in young adult rat offspring

Conclusions: These results improve understanding of the mechanism by which a maternal high fat diet affects their F1. In summary, MO programs sex-dependent F1 changes in insulin, glucose and lipid signaling pathways, leading to liver dysfunction and insulin resistance. Male adult MOF1 livers show global down-regulation of genes that are required for normal function of major liver metabolic pathways. This new knowledge is important for producing sex-specific interventions.结论：本研究结果加深了对母体高脂饮食影响其子一代（F1）的作用机制的理解。综上，母体高脂饮食（MO）可通过编程调控诱导子一代出现性别依赖性的胰岛素、葡萄糖及脂质信号通路改变，进而引发肝功能异常与胰岛素抵抗。成年雄性MOF1小鼠肝脏中，维持肝脏主要代谢通路正常功能所需的基因呈现整体下调表达。该研究成果可为开发性别特异性干预措施提供重要依据。