The Busselton Health Study data collected

A summary of surveys, data and biological specimens from the Busselton Health Study. The group, independently and in collaboration with other Busselton Health Studies researchers, uses the accumulated data to conduct research into:epidemiology of cardiovascular diseases; epidemiology of respiratory diseases; mortality and hospital admission rates; familial aggregation of chronic diseases; and disease risk factors. Most surveys included a detailed questionnaire focussing on lifestyle and general health history, a number of physical measurements and tests, and blood samples were collected for biochemical, haematological and immunological analyses. Cross-sectional comprehensive surveys of all adults on the electoral roll for Busselton Shire were conducted in 1966, 1969, 1972, 1975, 1978, and 1981 with respective participation rates of 91%, 90%, 86%, 76%, 74% and 64%. The number of participants ranged from 3,400 in 1966 to about 4,000 in 1978 and 1981. Cross-sectional comprehensive surveys of all school children were conducted in 1967, 1970, 1973, 1977 (high school only) and 1983. The number of participants was about 1,600 in each survey except for 1977 when it was 556. A cross-sectional comprehensive survey of all adults over 65 years of age was conducted in 1987. The number of participants was 1,120. A cross-sectional (respiratory questionnaire only) survey of all adults (on the electoral roll) was conducted in 1990. The number of respondents was 3,880. An asthma (questionnaire, sera and DNA) survey of 250 families (two parents and two children) was conducted in 1992. Mortality follow-up of all participants in the cross-sectional surveys 1966-1987 is performed annually, both by linkage to the Registrar-General's annual death list for Western Australia and by manual methods. All hospital admissions (1975 - 2003) for participants in the cross-sectional surveys 1966-1987 have been added to the database via linkage to the WA Hospital Morbidity Data System. Periodic updates will be performed. All 10,000 known survivors of the cross-sectional surveys (1966 - 1983) were invited to a comprehensive survey in 1994/95 regardless of whether or not still resident in Busselton. The response rate was about 50%. Sera for approximately 3,000 people are available from each cross-sectional survey of adults (1966, 1969, 1972, 1975, 1978, 1981) although there are identification problems with some batches of specimens and the integrity of the sera is not guaranteed due to variable quality storage facilities over the years. Pilot testing of a few specimens is strongly recommended. Sera are available for most people in the 250 families in the 1992 asthma survey. Sera are available for about 4,500 people in the 1994-95 follow-up survey. DNA for most people in the 250 families in the 1992 asthma family survey are available. Whole blood and buffy coats are available for about 4,500 people in the 1994-95 follow-up survey. Survey information on participants' relatives has been used to construct family pedigrees among Busselton survey participants. Using data from Adult and Childrens' surveys, the study has (incomplete) data for about 2,000 families. Using data from Adult surveys only, the study has (incomplete) data for 1,300 families. From adult surveys, the study has data on about 2,900 husband-wife pairs who took part in at least one survey together. The 1992 asthma family survey included 250 families with 2 parents and 2 children.

本数据集汇总了巴瑟尔顿健康研究（Busselton Health Study）的调研资料、数据与生物样本。该研究团队独立开展研究，并与其他巴瑟尔顿健康研究的研究者合作，依托积累的数据集开展以下方向的研究：心血管疾病流行病学、呼吸系统疾病流行病学、死亡率与住院率、慢性病家族聚集性，以及疾病风险因素。多数调研包含针对生活方式与一般健康史的详细问卷、多项身体测量与检测项目，并采集血液样本用于生化、血液学与免疫学分析。1966年、1969年、1972年、1975年、1978年与1981年，针对巴瑟尔顿郡登记选民中的全体成年人开展了横断面综合调研，对应参与率分别为91%、90%、86%、76%、74%与64%，参与者人数从1966年的3400人，到1978年与1981年的约4000人不等。1967年、1970年、1973年、1977年（仅针对高中阶段学生）与1983年，针对全体在校学龄儿童开展了横断面综合调研，各调研的参与者人数约为1600人，仅1977年为556人。1987年，针对全体65岁以上成年人开展了一项横断面综合调研，参与者人数为1120人。1990年，针对登记选民中的全体成年人开展了仅包含呼吸问卷的横断面调研，有效受访者共3880人。1992年，针对250个家庭（含2名父母与2名子女）开展了哮喘相关调研，涵盖问卷、血清与DNA样本采集。研究团队每年对1966-1987年横断面调研的所有参与者开展死亡率随访，通过与西澳大利亚州注册总署年度死亡名单联动，以及人工核查两种方式完成。通过与西澳医院发病数据系统（WA Hospital Morbidity Data System）联动，研究团队已将1975年至2003年间1966-1987年横断面调研参与者的所有住院记录纳入数据库，后续将定期更新该数据集。1994年至1995年，研究团队邀请1966-1983年横断面调研的全部10000名存活参与者参与综合调研，无论其是否仍居住在巴瑟尔顿地区，最终应答率约为50%。1966年、1969年、1972年、1975年、1978年、1981年的成人横断面调研中，各调研均可获取约3000人的血清样本，但部分批次样本存在标识问题，且由于多年来存储设施质量参差不齐，血清样本的完整性无法得到保证，强烈建议先对少量样本开展预实验检测。1992年哮喘调研的250个家庭中，多数受试者的血清样本均可获取；1994-1995年随访调研中，约4500人的血清样本可供使用。1992年哮喘家庭调研的250个家庭中，多数受试者的DNA样本可供获取；1994-1995年随访调研中，约4500人的全血与血沉棕黄层（buffy coats）样本可供使用。研究团队利用受试者亲属的调研信息，构建了巴瑟尔顿调研参与者的家族谱系。依托成人与儿童调研的数据，研究团队已获取约2000个家庭的（不完整）数据；仅依托成人调研的数据，研究团队已获取1300个家庭的（不完整）数据。从成人调研数据中，研究团队获取了约2900对至少共同参与过一项调研的夫妻的相关数据。1992年哮喘家庭调研共纳入250个家庭，每个家庭包含2名父母与2名子女。