In this study, we have uncovered novel proteolytic processing of the histone H3 tail in senescence models in primary fibroblasts and melanocytes. Cleavage of H3 tail occurs at two distinct residues an
DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) is essential for genome regulation and development. Dysregulation of this process is implicated in various diseases, notab
After wounding in plants, a vast and rapid transcriptional reprogramming takes place. Interestingly, this reprogramming includes the reactivation of developmental regulators that in mature tissue norm
We examined the genome-wide distribution of histone crotonylation and H3K27ac in human embryonic stem cells and induced endoderm cells, by obtaining over four billion bases of sequence from chromatin
Normalized ChIP-seq datasets for visualization in IGV. The tracks contain means of pooled replicate datasets. ChIP-seq data were quality-filtered and adapters removed with trimmomatic v.0.39 (Bolger e
