The DIRECT Trial: Daily vs Intermittent Restriction of Energy: Randomised Controlled Trial to Reduce Diabetes Risk

This dataset includes 260 non-diabetic men and women aged 35-75 years, BMI 25−50 kg/m2 with score ≥12 on the Australian Diabetes Risk (AUSDRISK) calculator were recruited into this open-label, multi-arm, parallel group sequential randomized controlled trial. Participants were randomized to one of three groups for 18 months: IF (30% of energy needs on fast days), CR (70% of energy needs daily), or standard care (SC) group. All participants visited the clinic fortnightly for weight assessments during active intervention phase (6 months), followed by a 12-month follow-up phase.